http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47574235/?sort=date&direction=ascending

Manuscripts

  1. Anderson SE, Han WM, Srinivasa V, Mohiuddin M, Ruehle MA, Moon JY, Shin E, San Emeterio CL, Ogle ME, Botchwey EA, Willett NJ, Jang YC. Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps. Tissue Eng Part C Methods. 2019 Feb;25(2):59-70. doi: 10.1089/ten.TEC.2018.0324. PubMed PMID: 30648479.

  2. Kamalakar A, Oh MS, Stephenson YC, Ballestas-Naissir SA, Davis ME, Willett NJ, Drissi HM, Goudy SL. A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells. Cell Signal. 2019 Feb;54:130-138. doi: 10.1016/j.cellsig.2018.12.002. Epub 2018 Dec 8. PubMed PMID: 30529759.

  3. McKinney JM, Doan TN, Wang L, Deppen J, Reece DS, Pucha KA, Ginn S, Levit RD, Willett NJ. Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis. Eur Cell Mater. 2019 Jan 29;37:42-59. doi: 10.22203/eCM.v037a04. PubMed PMID: 30693466.

  4. Ruehle MA, Li MA, Cheng A, Krishnan L, Willett NJ, Guldberg RE. Decorin-supplemented collagen hydrogels for the co-delivery of bone morphogenetic protein-2 and microvascular fragments to a composite bone-muscle injury model with impaired vascularization. Acta Biomater. 2019 Jan 25. pii: S1742-7061(19)30065-0. doi: 10.1016/j.actbio.2019.01.045. [Epub ahead of print] PubMed PMID: 30685477.

  5. Ruehle MA, Krishnan L, Vantucci CE, Wang Y, Stevens HY, Roy K, Guldberg RE, Willett NJ. Effects of BMP-2 dose and delivery of microvascular fragments on healing of bone defects with concomitant volumetric muscle loss. J Orthop Res. 2019 Jan 16. doi: 10.1002/jor.24225. [Epub ahead of print] PubMed PMID: 30648751.

  6. Sago CD, Lokugamage MP, Paunovska K, Vanover DA, Monaco CM, Shah NN, Gamboa Castro M, Anderson SE, Rudoltz TG, Lando GN, Munnilal Tiwari P, Kirschman JL, Willett N, Jang YC, Santangelo PJ, Bryksin AV, Dahlman JE. High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9944-E9952. doi: 10.1073/pnas.1811276115. Epub 2018 Oct 1. Erratum in: Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11427. PubMed PMID: 30275336; PubMed Central PMCID: PMC6196543.

  7. Bariteau JT, Kadakia RJ, Traub BC, Viggeswarapu M, Willett NJ. Impact of Vancomycin Treatment on Human Mesenchymal Stromal Cells During Osteogenic Differentiation. Foot Ankle Int. 2018 Aug;39(8):954-959. doi: 10.1177/1071100718766655. Epub 2018 Apr 5. PubMed PMID: 29620948.

  8. Tellier LE, Treviño EA, Brimeyer AL, Reece DS, Willett NJ, Guldberg RE, Temenoff JS. Intra-articular TSG-6 delivery from heparin-based microparticles reduces cartilage damage in a rat model of osteoarthritis. Biomater Sci. 2018 May 1;6(5):1159-1167. doi: 10.1039/C8BM00010G. PubMed PMID: 29564448.

  9. Tellier LE, Krieger JR, Brimeyer AL, Coogan AC, Falis AA, Rinker TE, Schudel A, Thomas SN, Jarrett CD, Willett NJ, Botchwey EA, Temenoff JS. Localized SDF-1α Delivery Increases Pro-Healing Bone Marrow-Derived Cells in the Supraspinatus Muscle Following Severe Rotator Cuff Injury. Regen Eng Transl Med. 2018 Jun;4(2):92-103. doi: 10.1007/s40883-018-0052-4. Epub 2018 Apr 23. PubMed PMID: 30288396; PubMed Central PMCID: PMC6166879.

  10. Ahn H, Patel RR, Hoyt AJ, Lin ASP, Torstrick FB, Guldberg RE, Frick CP, Carpenter RD, Yakacki CM, Willett NJ. Biological evaluation and finite-element modeling of porous poly(para-phenylene) for orthopaedic implants. Acta Biomater. 2018 May;72:352-361. doi: 10.1016/j.actbio.2018.03.025. Epub 2018 Mar 18. PubMed PMID: 29563069; PubMed Central PMCID: PMC5938097.

  11. Reece DS, Thote T, Lin ASP, Willett NJ, Guldberg RE. Contrast enhanced μCT imaging of early articular changes in a pre-clinical model of osteoarthritis. Osteoarthritis Cartilage. 2018 Jan;26(1):118-127. doi: 10.1016/j.joca.2017.10.017. Epub 2017 Oct 28. PubMed PMID: 29107695.

  12. Klosterhoff BS, Ghee Ong K, Krishnan L, Hetzendorfer KM, Chang YH, Allen MG, Guldberg RE, Willett NJ. Wireless Implantable Sensor for Noninvasive, Longitudinal Quantification of Axial Strain Across Rodent Long Bone Defects. J Biomech Eng. 2017 Nov 1;139(11). doi: 10.1115/1.4037937. PubMed PMID: 28975256; PubMed Central PMCID: PMC5676651.

  13. Caroti CM, Ahn H, Salazar HF, Joseph G, Sankar SB, Willett NJ, Wood LB, Taylor WR, Lyle AN. A Novel Technique for Accelerated Culture of Murine Mesenchymal Stem Cells that Allows for Sustained Multipotency. Sci Rep. 2017 Oct 17;7(1):13334. doi: 10.1038/s41598-017-13477-y. PubMed PMID: 29042571; PubMed Central PMCID: PMC5645326.

  14. Ruehle MA, Krishnan L, LaBelle SA, Willett NJ, Weiss JA, Guldberg RE. Decorin-containing collagen hydrogels as dimensionally stable scaffolds to study the effects of compressive mechanical loading on angiogenesis. MRS Commun. 2017 Sep;7(3):466-471. doi: 10.1557/mrc.2017.54. Epub 2017 Jul 20. PubMed PMID: 29450108; PubMed Central PMCID: PMC5810960.

  15. Li MT, Ruehle MA, Stevens HY, Servies N, Willett NJ, Karthikeyakannan S, Warren GL, Guldberg RE, Krishnan L. * Skeletal Myoblast-Seeded Vascularized Tissue Scaffolds in the Treatment of a Large Volumetric Muscle Defect in the Rat Biceps Femoris Muscle. Tissue Eng Part A. 2017 Sep;23(17-18):989-1000. doi: 10.1089/ten.TEA.2016.0523. Epub 2017 Aug 23. PubMed PMID: 28372522; PubMed Central PMCID: PMC5610391.

  16. Schwartz AM, Schenker ML, Ahn J, Willett NJ. Building better bone: The weaving of biologic and engineering strategies for managing bone loss. J Orthop Res. 2017 Sep;35(9):1855-1864. doi: 10.1002/jor.23592. Epub 2017 May 23. Review. PubMed PMID: 28467648.

  17. Klosterhoff BS, Tsang M, She D, Ong KG, Allen MG, Willett NJ, Guldberg RE. Implantable Sensors for Regenerative Medicine. J Biomech Eng. 2017 Feb 1;139(2). doi: 10.1115/1.4035436. Review. PubMed PMID: 27987300; PubMed Central PMCID: PMC5253675.

  18. Willett NJ, Krishnan L, Li MT, Guldberg RE, Warren GL. Guidelines for Models of Skeletal Muscle Injury and Therapeutic Assessment. Cells Tissues Organs. 2016;202(3-4):214-226. Epub 2016 Nov 9. Review. PubMed PMID: 27825151.

  19. Willett NJ, Thote T, Hart M, Moran S, Guldberg RE, Kamath RV. Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography. Osteoarthritis Cartilage. 2016 Sep;24(9):1604-12. doi: 10.1016/j.joca.2016.04.021. Epub 2016 May 4. PubMed PMID: 27155345.

  20. Dosier CR, Uhrig BA, Willet NJ, Krishnan L, Li MA, Stevens HY, Schwartz Z, Boyan BD, Guldberg RE. “Effect of Cell Type and Timing of Delivery for Cell Based Bone Tissue Engineering in a Critically Sized Femoral Segmental Defect Utilizing Biologically Functionalized Hydrogels.” Tissue Engineering Part A. 2015 Jan; 21(1-2):156-65.

  21. Singh A, Diaz C, Agarwal R, Willett NJ, Lee A, Wang Q, Guldberg RE, Garcia AJ. “Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.” Advanced Healthcare Materials. 2014 Oct; 3(10):1562-7, 1525.

  22. Priddy LB, Chaudhuri O, Stevens HY, Krishnan L, Uhrig BA, Willett NJ, Guldberg RE. Oxidized alginate hydrogels for bone morphogenetic protein-2 delivery in long bone defects. Acta Biomater. 2014 Oct;10(10):4390-9. doi: 10.1016/j.actbio.2014.06.015. Epub 2014 Jun 17. PubMed PMID: 24954001; PubMed Central PMCID: PMC4160396.

  23. Li MT, Willett NJ, Uhrig BA, Guldberg RE, Warren GL. Functional analysis of limb recovery following autograft treatment of volumetric muscle loss in the quadriceps femoris. J Biomech. 2014 Jun 27;47(9):2013-21. doi: 10.1016/j.jbiomech.2013.10.057. Epub 2013 Nov 11. PubMed PMID: 24280565; PubMed Central PMCID: PMC4017006.

  24. Willett NJ*, Thote T*, Lin A, Moran SM, Raji Y, Guldberg RE. “Micronized Amnion Attenuates Osteoarthritis Disease Development in a Rat Model.” Arthritis Research & Therapy. 2014 Feb 6;16(1):R47.

  25. Krishnan L, Willett NJ, Guldberg RE. “Vascularization Strategies in Musculoskeletal Regeneration.” Annals of Biomedical Engineering. 2014 Feb; 42(2): 432-44.

  26. Stevens HY, Shockley BE, Willett NJ, Lin AS, Raji Y, Labib S, Guldberg RE. “Particulated Juvenile Articular Cartilage Implantation in the Knee, a Three Year EPIC-mCT and Histological Examination.” Cartilage, April 2014 vol. 5 no. 2 74-77.

  27. Thote T, Lin A, Raji Y, Moran SM, Stevens HY, Kamath R, Hart M, Guldberg RE, Willett NJ. “Localized 3D Analysis of Cartilage Composition and Morphology in Small Animal Models of Joint Degeneration.” Osteoarthritis and Cartilage, 2013 Aug; 21(8):1132-41.

  28. Uhrig BA, Boerckel JD, Willett NJ, Li M A, Huebsch N, Guldberg R E. “The Effect of Limb Ischemia on BMP-2-mediated Segmental Bone Defect Repair.” Bone, 2013 May 7; 55(2):410-417.

  29. Willett NJ, Li MA, Uhrig BA, Boerckel JD, Lundgren T, Huebsch N, Guldberg RE. “Attenuated rhBMP-2 Mediated Bone Regeneration in a Rat Model of Composite Bone and Muscle Injury.” Tissue Engineering Part C, 2013 April, 19; (4): 316-25.

  30. Boerckel JD, Uhrig BA, Willett NJ, Huebsch N, Guldberg RE. “Mechanical Regulation of Vascular Growth and Tissue Regeneration In Vivo.” Proc Natl Acad Sci USA, 2011 Sep 13; 109(37): E674-80.

  31. Willett NJ, Kundu K, Knight SF, Dikalov S, Murthy N, Taylor WR. “Redox Signaling in an In Vivo Murine Model of Tailored Wall Shear Stress.” Antioxid and Redox Signaling, 2011 Sep 1; 15(5): 1369-78.

  32. Willett NJ, Long RC Jr, Maiellaro-Rafferty K, Sutliff RL, Schafer R, Oshinski JN, Giddens DP, Guldberg RE, Taylor WR. “An In Vivo Murine Model of Low-Magnitude Oscillatory Wall Shear Stress to Address the Molecular Mechanisms of Mechanotransduction. ” Arterioscler Thromb Vasc Biol, 2010 Nov; 30(11): 2099-102.

  33. Amirbekian S, Long RC Jr., Consolini MA, Suo J, Willett NJ, Fielden SW, Giddens DP, Taylor WR, Oshinski JN. "In-Vivo Assessment of Blood Flow Patterns in the Abdominal Aorta of Mice Using MRI: Implications for AAA Localization." Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4).

  34. Kundu K., Knight S, Willett N, Lee S, Taylor WR, Murthy N. "Hydrocyanines: A New Class of Fluorescent Sensors That Can Image Reactive Oxygen Species in Cell Culture, Tissue and In Vivo." ANGEWANDTE CHEMIE, Int Ed Engl, 2009. 48(2): p. 299-303.

  35. Gall, K., Yakacki CM, Liu Y, Shandas R, Willett N, Anseth KS. (2005). "Thermomechanics of the shape memory effect in polymers for biomedical applications." J Biomed Mater Res A 73(3): 339-48.

Book Chapters

  1. Diab T, Willett NJ, Guldberg R E. “Principles of Tissue Engineering in Orthopaedics.” Orthopaedic Basic Science: Foundations of Clinical Practice, Fourth Edition. Ed. OKeefe RJ, Jacobs JJ, Chu CR, Einhorn TA. American Academy of Orthopaedic Surgeons. January 2013.

  2. Thote T, Moran SM, Lin A, Willett NJ, Neu CP, Guldberg RE. “Imaging Methods for the Detection of Joint Degeneration.” Advances in Biomedical Imaging. Ed. Morris P. Woodhead Pub. In Press.

  3. Uhrig BA, Li MA, Willett NJ, Guldberg RE. “Composite Tissue Limb Regeneration.” Biomaterials and Regenerative Medicine. Ed. Peter X. Ma. Cambridge: Cambridge University Press. 9/2014.

* – Authors contributed equally to this work